P05 Poeck, Ruland
Role of innate immune signals and microbiota on intestinal epithelial regeneration in graft-versus-host disease
Principal Investigators:
Poeck, Hendrik, TUM & UKR
Ruland, Jürgen, TUM
Innate immune signaling and gut microbiota considerably affect the outcome of graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation. Using antifungal/antibacterial regimens and unique gnotobiotic animal models in an experimental setting of GvHD, we aim to understand the contribution of specific innate immune pathways and microbiota-dependent factors on intestinal stem cell function and epithelial barrier regeneration.
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