P07 Ohnmacht, Zehn
Microbiota-mediated modulation of adaptive immunity
Principal Investigators:
Ohnmacht, Caspar, TUM
Zehn, Dietmar, TUM
In P07, we make use of a viral infection model (LCMV) to investigate how microbial particularities of the microbiota impact the adaptive immune response to viral infections. For this purpose, we will use gnotobiotic mice colonized with natural variations of complex microbial communities and defined minimal consortia (Oligo-MM) and assess in parallel how changes in the mucosal immune system including innate immune cells and Foxp3+ regulatory T cells mechanistically impact the antigen-specific cytotoxic T cell response during acute and chronic LCMV infections.
⇒ Projects