P09 Deng, Gerhard
Helicobacter infection and microbiota-dependent colonic pathologies
Principal Investigators:
Deng, Li, HMGU
Gerhard, Markus, TUM
Helicobacter pylori not only induces gastric cancer but also appears to impact colonic carcinogenesis. We hypothesize that chronic H. pylori infection induces changes in the composition of the gastrointestinal microbiota, thereby promoting carcinogenesis. We will characterize the influence of
H. pylori infection on intestinal/colonic inflammation and tumorigenesis and decipher the microbiome signatures involved. These will be further explored in H. pylori-infected patients with colonic pathologies. As a therapeutic approach, we will identify specific bacteriophages using a “viral tagging” approach and test lytic phages for the treatment of H. pylori infection in mice without disruption of the endogenous microbiota.
The PIs are initiators and members of the Munich Virome Research Consortium, a new initiative for researchers working on the microbiome and virome in Munich.
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