P11 Tschurtschenthaler
Deciphering the role of tumor-site specific dysbiosis in subtypes of colorectal cancer
Principal Investigator:
Tschurtschenthaler, Markus, TUM
We aim to decipher colorectal cancer subtype-specific bacterial risk profiles and to delineate host-microbiota interactions that are relevant for tumor-initiation and progression using mouse models of BrafV637E, KrasG12D, Pik3caH1047R and Apc1638N-driven tumors. Orthotopic transplantations of organoids derived from these mice will be performed to functionally analyze the impact of various environments, i.e. SPF, germ-free and inflammatory conditions, on tumor initiation and progression with the long-term aim of targeting tumor-promoting taxa and bacterial signals.
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