Sub-Projects of SFB 1035

Here you will find an overview of the sub-projects of SFB 1035. Click on the project designation to get a detailed description. Further information about the sub-project managers is provided on the page project managers.

Sub-Project Division A: Structural switching in folded proteins

A01	Prof. Wolfgang Baumeister Dr. Eri Sakata	MPI für Biochemie Martinsried	The 26S Proteasome: Dynamics of the regulatory particle
A02	Prof. Michael Groll	TUM, Department Chemie Garching	Positioning, association and maturation of subunits during 20S proteasome assembly in pro- and eukaryotes
A03	Prof. Johannes Buchner Prof. Michael Sattler	TUM, Department Chemie Garching	Conformational regulation of the Hsp90 machinery
A04	Dr. Serena Schwenkert	Biozentrum der LMU München Department Biologie I, Botanik Martinsried	Chaperones and TPR proteins in organellar protein import and chloroplast biogenesis
A05	Prof. Matthias Rief	TUM, Department Physik Garching	Mechanical control of protein conformations
A06	Prof. Sevil Weinkauf Dr. Martin Haslbeck Prof. Johannes Buchner	TUM, Department Chemie Garching	Conformational plasticity of small Hsps
A07	Prof. PD Dr. Elena Conti	MPI für Biochemie Martinsried	Regulation of the DEAD-box RNA helicase Sub2 by TREX
A09	Prof. Stephan Sieber	TUM, Department Chemie Garching	Small molecule induced conformational control of protein function and activity
A10 (exp.)	Prof. Iris Antes +2021	TUM, WZW Freising-Weihenstephan	Conformational switching induced by protein-ligand assembly
A11	Prof. Don C. Lamb	LMU, Department Chemie München	Single molecule fluorescence methods for investigating conformational dynamics and allosteric effects in chaperones
A12	Dr. Manajit Hayer-Hartl Prof. Franz-Ulrich Hartl	MPI für Biochemie Martinsried	Mechanisms of chaperone-mediated protein folding and assembly
A13	Prof. Brenda Schulman	MPI für Biochemie Martinsried	Conformational switching during the production of branched polyubiquitin chains
A14	Prof. Cathleen Zeymer	TUM, Department Chemie Garching	Engineering conformational dynamics of a de novo designed two-domain metalloenzyme

Sub-Project Division B: Mechanisms influencing conformational diversity

B01 (exp.)	Prof. Thomas Kiefhaber	TUM, Department Chemie Garching	Coupled binding and folding reactions of intrinsically disordered proteins
B02	Prof. Martin Zacharias	TUM, Department Physik Garching	Association-induced conformational switching in biomolecules studied by Molecular Dynamics simulations
B03	Prof. Michael Sattler	TUM, Department Chemie Garching	Conformational control of multi-domain RNA binding proteins
B04 (exp.)	PD Dr. Sonja A. Dames	TUM, Department Chemie Garching	Regulation mechanisms and dynamic properties of mycobacterial protein kinase G
B05	Prof. Aymelt Itzen	UKE, Institut für Biochemie und Signaltransduktion Hamburg	Structural dynamics of small GTPases under the influence of posttranslational modifications
B06	Prof. Aphrodite Kapurniotu	TUM, WZW Freising-Weihenstephan	Exploiting cross-amyloid interfaces to design peptides as modulators of amyloid self-assembly
B07	Prof. Bernd Reif	TUM, Department Chemie Garching	Structural analysis of inhibitor-amyloid co-aggregates
B08 (see: AP02)	Prof. Ralf Zimmer Dr. Martin Haslbeck	Department Informatik, LMU München TUM, Department Chemie, Garching	Alternative Splicing – switching and conformational diversity
B09 (exp.)	Dr. Oliver F. Lange	TUM, Department Chemie Garching	Design of alternative protein conformations
B10 (exp.)	Prof. Kathrin Lang	ETH, Department Chemie Zürich	Genetic code expansion tools to study and control conformational dynamics and protein assembly
B11	Prof. Matthias Feige	TUM, Department Chemie Garching	Structural mechanisms and cellular regulation of assembly-induced protein folding
B12 (exp.)	Prof. Ville R. I. Kaila	TUM, Department Chemie Garching	Multi-scale molecular simulations and artificial design of long-range conformational switches
B13	Prof. Franz Hagn	TUM, Department Chemie Garching	Conformational switching of Bcl2 proteins and their complexes in a native membrane environment
B14	Prof. Danny Nedialkova	MPI für Biochemie Martinsried	Translational control of protein folding by elongation kinetics
B15	Prof. Anne Schütz	LMU, Department Chemie München	Conformational switches in viral regulatory proteins

Associated Projects

AP01 (see: A12)	Prof. F. Ulrich Hartl	MPI of Biochemistry Department Cellular Biochemistry Martinsried	Conformational changes during chaperonin-assisted protein folding
AP02	Prof. Ralf Zimmer Dr. Martin Haslbeck	Department Informatics, LMU München TUM, Department of Chemistry, Garching	Alternative Splicing - switching and conformational diversity
AP03 (see: B14)	Prof. Danny Nedialkova	MPI of Biochemistry  Department Mechanisms of Protein Biogenesis and  TUM, Department of Chemistry, Garching  Biochemistry of Gene Expression	Translational control of protein folding by ribosome transit kinetics
AP04 (see: A13)	Prof. Brenda A. Schulman	MPI of Biochemistry  Department Molecular Machines and Signaling	Conformational changes during ubiquitin and ubiquitin-like protein conjugation
AP05 (see: B15)	Dr. Anne Schütz	TUM, Department of Chemistry Garching	Conformational switching in viral regulatory proteins
AP06	Prof. Wolfgang Bausmeister Dr. Eri Sakata	MPI of Biochemistry  Department Molecular Structural Biology	The 26S Proteasome: Dynamics of the regulatory particle
AP07	Prof. Jürgen Soll Dr. Serena Schwenkert	Faculty of Biology, Biocenter LMU München	Chaperones and TPR proteins in organellar protein import and chloroplast biogenesis
AP08	Prof. Ville R. I. Kaila	Department of Biochemistry and Biophysics (DBB), Stockholm University	Multi-scale molecular simulations and artificial design of long-range conformational switches
AP09	Prof. Thorben Cordes	Department Biology I, LMU München	Single-molecule studies of conformational switching and activation of the sodium-coupled symporter BetP

Sub-Project Division Z

Z1

Prof. Johannes Buchner Prof. Michael Sattler

TUM, Department Chemie Garching

Biophysical methods