Sub-Projects of SFB 1035

Here you will find an overview of the sub-projects of SFB 1035. Click on the project designation to get a detailed description. Further information about the sub-project managers is provided on the page project managers.

Sub-Project Division A: Structural switching in folded proteins

A01 Prof. Wolfgang Baumeister
Dr. Eri Sakata
MPI für Biochemie
Martinsried
The 26S Proteasome: Dynamics of the regulatory particle
A02 Prof. Michael Groll TUM, Department Chemie
Garching
Positioning, association and maturation of subunits during 20S proteasome assembly in pro- and eukaryotes
A03 Prof. Johannes Buchner
Prof. Michael Sattler
TUM, Department Chemie
Garching
Conformational regulation of the Hsp90 machinery
A04 Dr. Serena Schwenkert Biozentrum der LMU München
Department Biologie I, Botanik
Martinsried
Chaperones and TPR proteins in organellar protein import and chloroplast biogenesis
A05 Prof. Matthias Rief TUM, Department Physik
Garching
Mechanical control of protein conformations
A06 Prof. Sevil Weinkauf
Dr. Martin Haslbeck
Prof. Johannes Buchner
TUM, Department Chemie
Garching
Conformational plasticity of small Hsps
A07 Prof. PD Dr. Elena Conti MPI für Biochemie
Martinsried
Regulation of the DEAD-box RNA helicase Sub2 by TREX
A09 Prof. Stephan Sieber TUM, Department Chemie
Garching
Small molecule induced conformational control of protein function and activity

A10 (exp.)

Prof. Iris Antes
+2021
TUM, WZW
Freising-Weihenstephan
Conformational switching induced by protein-ligand assembly
A11 Prof. Don C. Lamb LMU, Department Chemie
München
Single molecule fluorescence methods for investigating conformational dynamics and allosteric effects in chaperones
A12 Dr. Manajit Hayer-Hartl
Prof. Franz-Ulrich Hartl
MPI für Biochemie
Martinsried
Mechanisms of chaperone-mediated protein folding and assembly
A13 Prof. Brenda Schulman MPI für Biochemie
Martinsried
Conformational switching during the production of branched polyubiquitin chains
A14 Prof. Cathleen Zeymer TUM, Department Chemie
Garching

Engineering conformational dynamics of a de novo designed two-domain metalloenzyme

Sub-Project Division B: Mechanisms influencing conformational diversity

B01 (exp.) Prof. Thomas Kiefhaber TUM, Department Chemie
Garching
Coupled binding and folding reactions of intrinsically disordered proteins
B02 Prof. Martin Zacharias TUM, Department Physik
Garching
Association-induced conformational switching in biomolecules studied by Molecular Dynamics simulations
B03 Prof. Michael Sattler TUM, Department Chemie
Garching
Conformational control of multi-domain RNA binding proteins
B04 (exp.) PD Dr. Sonja A. Dames TUM, Department Chemie
Garching
Regulation mechanisms and dynamic properties of mycobacterial protein kinase G
B05 Prof. Aymelt Itzen UKE, Institut für Biochemie und Signaltransduktion
Hamburg
Structural dynamics of small GTPases under the influence of posttranslational modifications
B06 Prof. Aphrodite Kapurniotu TUM, WZW
Freising-Weihenstephan
Exploiting cross-amyloid interfaces to design peptides as modulators of amyloid self-assembly
B07 Prof. Bernd Reif TUM, Department Chemie
Garching
Structural analysis of inhibitor-amyloid co-aggregates
B08 (see: AP02) Prof. Ralf Zimmer
Dr. Martin Haslbeck
Department Informatik, LMU München
TUM, Department Chemie, Garching
Alternative Splicing – switching and conformational diversity
B09 (exp.) Dr. Oliver F. Lange TUM, Department Chemie
Garching
Design of alternative protein conformations
B10 Prof. Kathrin Lang ETH, Department Chemie
Zürich
Genetic code expansion tools to study and control conformational dynamics and protein assembly
B11 Prof. Matthias Feige TUM, Department Chemie
Garching
Structural mechanisms and cellular regulation of assembly-induced protein folding
B12 (exp.) Prof. Ville R. I. Kaila TUM, Department Chemie
Garching
Multi-scale molecular simulations and artificial design of long-range conformational switches
B13 Prof. Franz Hagn TUM, Department Chemie
Garching
Conformational switching of Bcl2 proteins and their complexes in a native membrane environment
B14 Prof. Danny Nedialkova MPI für Biochemie Martinsried

Translational control of protein folding by elongation kinetics

B15 Dr. Anne Schütz TUM, Department Chemie
Garching
Conformational switches in viral regulatory proteins

Associated Projects

AP01 (see: A12) Prof. F. Ulrich Hartl MPI of Biochemistry
Department Cellular Biochemistry
Martinsried
Conformational changes during chaperonin-assisted protein folding
AP02 Prof. Ralf Zimmer
Dr. Martin Haslbeck
Department Informatics, LMU München
TUM, Department of Chemistry, Garching
Alternative Splicing - switching and conformational diversity
AP03 (see: B14) Prof. Danny Nedialkova MPI of Biochemistry 
Department Mechanisms of Protein Biogenesis and 
TUM, Department of Chemistry, Garching 
Biochemistry of Gene Expression
Translational control of protein folding by ribosome transit kinetics
AP04 (see: A13) Prof. Brenda A. Schulman MPI of Biochemistry 
Department Molecular Machines and Signaling
Conformational changes during ubiquitin and ubiquitin-like protein conjugation
AP05 (see: B15) Dr. Anne Schütz TUM, Department of Chemistry
Garching
Conformational switching in viral regulatory proteins
AP06

Prof. Wolfgang Bausmeister

Dr. Eri Sakata

MPI of Biochemistry 
Department Molecular Structural Biology

The 26S Proteasome: Dynamics of the regulatory particle

AP07

Prof. Jürgen Soll

Dr. Serena Schwenkert

Faculty of Biology, Biocenter LMU München
 
Chaperones and TPR proteins in organellar protein import and chloroplast biogenesis
AP08 Prof. Ville R. I. Kaila Department of Biochemistry and Biophysics (DBB), Stockholm University Multi-scale molecular simulations and artificial design of long-range conformational switches
AP09 Prof. Thorben Cordes Department Biology I, LMU München Single-molecule studies of conformational switching and activation of the sodium-coupled symporter BetP

Sub-Project Division Z

Z1 Prof. Johannes Buchner
Prof. Michael Sattler
TUM, Department Chemie
Garching